It is our hope that this guide inspires practitioners around the country to pursue actions that reduce traffic pollution while also encouraging and enabling more children to safely walk and bicycle in cleaner air. This publication examines the following: the health impacts on children from exposure to traffic pollution; how Safe Routes to School programs can potentially impact children’s exposure to traffic pollution; and strategies and practice approaches that can mitigate exposure to traffic pollution. This publication was made possible through support from the Centers for Disease Control and Prevention and the American Public Health Association.